The usefulness of angiopoietin-1 as biomarker in missed abortion

Authors

  • Maha Mohammed Jasim Al Bayati Department of Obstetrics and Gynecology, Al Yarmouk hospital, Ministry of Health, Baghdad, Iraq.
  • Sahar Abdul Baqi Sabti Al Dulaimi Department of Obstetrics and Gynecology, Al Yarmouk hospital, Ministry of Health, Baghdad, Iraq.
  • Mayasah Abbas Abed Department of Obstetrics and Gynecology, Al Yarmouk hospital, Ministry of Health, Baghdad, Iraq.

DOI:

https://doi.org/10.22317/imj.v6i3.1194

Keywords:

Angiopoietin-1, Biomarkers, Abortion, Missed

Abstract

Objective: To detect serum angiopoietin -1 level as effective biomarker for missed abortion in early pregnancy.

Methods: The study included 100 pregnant women; 50 pregnant women with missed abortion (group A) and 50 pregnant women with viable intrauterine pregnancy in first trimester (group B). Both groups were test for serum level of angiopoietin -1 using   Enzyme linked immunosorbent assay technique.

Results: The mean serum angiopoietin -1 level is significantly decrease in missed abortion compare with control group women (771.12 ± 165 VS 1381.12 ± 340.36) respectively at P value (0.001). There was correlation between missed abortion and (body mass index, reproductive history) in groups of study.

Conclusion: The current study showed that serum levels of angiopoitin-1 are significantly decrease in pregnant women with missed abortion compared with its level in normal viable intrauterine pregnancy of matched gestation.

References

Hoffman, B.L., and Williams, J.W. First-Trimester Abortion. In: Williams gynecology. 3rd Edition. McGraw Hill Education, New york 2016;6; p 137-139 .

CALVIN J. HOBEL. JOHN WILLIAMS lll. Antepartum care. NEVILLE F. Hacker, Joseph C. Gambone, calrin J. Hobel, MD, In: Hacker & Moore's essentials of obstetrics and gynecology. 6th edition. John F. Kennedy Blvd, canada 2016; 7; p79-81.

Lawrence Impey and Tim child. Disorder of early pregnancy. In: Obstetrics & gynecology.4th edition. AJohn Wily & sons, Ltd 2012;14; p 118-121.

David J. CAHILL, REBECCA SWINGLER, and PETER G. WARDLE. Bleeding and pain in early pregnancy. David James, Philps J. steer. In: High Risk pregnancy. 4th edition. Saunder, 2011;5; 57-74.

Najah Shaker Yassen 1 , Hiyam Jasim Mohammed2, “Serum Angiopoietin-1 & Angiopoietin-2 as Serum Biomarkers for Ectopic Pregnancy and Missed Miscarriage”, IJPHRD, vol. 11, no. 7, pp. 1391-1396, Jul. 2020.

Rao, M., Kanwal, S., Mahmud, Q., Qureshi, H.J., and Zulfiqar, S.: ‘Serum angiopoietin-1 as a biomarker of missed abortion’, Pakistan Journal of Physiology, 2018, 14, (2), pp. 15-17.

Robert Casanova, Alice Chuang, Charles R.B. Beckmann, Frank wiling. Ectopic pregnancy & abortion. In: Beckmann and Ling's obstetrics and gynecology. 8th edition. Wolters Kluwer, 2019;19; p429-433.

Zhao, R., et al., The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman: A case control study in Chinese women. Medicine, 2017, 96 (51): p. e9388-e9388.

Sanaz Keyhan, Lisa Muacher, Suheil J. Muacher. Spontaneous abortion & recurrent pregnancy loss. Roger A. Lobo, MD, David M. Gershenson. MD, Gretchen M. Lentz, MD, Fidel A. Valea.MD, In: Comprehensive gynecology.7th edition. John F. Kennedy Blvd, 2017; 16; 330 – 342.

Christine l, Ekechi and catriona M. stalder. Spontaneous Miscarrage. D.keith Edmonds MB,ChB, FRCOG, FRANZCOG. In : Dewhurst's Textbook of Obstetrics and Gynaecology. 9th Edition, John Wiley & son Ltd,London 2018;40; p559-562.

F. Gary Cunningham, Kenneth J.Levendo, steven L. Bloom, Barbara L. Hoffman. Abortion. In: Williams obstetrics, 25th Edition, Mc Graw- Hill eduction, 2018;18; 347-354.

ACOG Practice Bulletin No. 200 Summary: Early Pregnancy Loss. Obstet Gynecol 2018; 132 (5):1311-1313.

E. Destegul, S. Gencdal, I. Sari, H. Akkaya, B. Cakmak, and N. Gencidal, "Maternal serum levels of SCUBIE1 in missed abortion, "Clinical and Experimental Obstetrics and Gynecology, vol. 47, pp. 862-866,2020.

Yang J, Wang Y, Wang X, Zhao Y, Wang J, Zhao Y. Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion. Bio Med Research International 2017; 2017:4359424.

Shuo Yang, Dandan Chen, Junxiong Wang et al. Coagulation Status in Women With Missed Abortion, 10 February 2021, PREPRINT (Version 1) available at Research Square.

H. M. Abozeid, B. N. Ali, H. W. Abdel Halim, and N. M. Abd Elbaky, "Serum angiopoietin-1 as a biomarker of missed abortion," Journal of Recent Advances in Medicine, vol. 2, pp. 112-117, 2021.

Alsamarai AM, Majeed HM, Alobaidi AH. Interleukin-6 [Il-6], Interleukin-17 [Il-17] and Angiopoietin in Women with Bad Obstetric History Kirkuk, Iraq. American Research Journal of Hematology (ARJh) 2016; 1: 1-11.

Downloads

Published

2022-09-26

How to Cite

1.
Al Bayati MMJ, Al Dulaimi SABS, Abed MA. The usefulness of angiopoietin-1 as biomarker in missed abortion. Iraq Med J [Internet]. 2022 Sep. 26 [cited 2024 Nov. 21];6(3). Available from: https://iraqmedj.org/index.php/imj/article/view/1194

Issue

Section

Articles

Most read articles by the same author(s)