Polymorphisms of the IL1-BETA-511T/C gene in pregnant women complicated with pre-eclampsia

Abstract

Objective Identify the association between single nucleotide polymorphisms (SNP) of IL-1 Beta and the onset and severity of the disease. Pre-eclampsia (PE) is a relatively common, systemic pregnancy disorder characterized by the development of concurrent hypertension (>140/90 mmHg) and proteinuria (>300 mg/24 h) at ≥20 weeks of gestation, that may also be associated with a myriad of other symptoms such as edema, headache, blurred vision, irritability, abdominal pain, and thrombocytopenia.
Methods The extracted DNA was amplified for IL-1 Beta RFLP in 60 clinically diagnosed preeclampsia pregnant women and 60 normotensive pregnant women. For statistical significance, OR was measured and all data were processed by using SPSS.
Results IL-1 Beta genotyping in PE pregnant women showed the following results TT genotype having 2.33 fold risk of having PE and etiological factor (0.57) while TC mutant genotype showed 1.125 fold risk of having PE etiological factor of (0.111), while homozygous CC genotype considered as protective genotype with protective factor of (0.674). T allele considered the etiological factor of (0.287) while C allele considered as protective allele with protective factor of (0.589).
Conclusion IL-1 Beta T allele considered as significant risk factor for having preeclampsia. The presence of IL-1 Beta C alleles protects against having preeclampsia.