Assessment of serum uric acid level in patients with systemic arterial hypertension

Authors

  • Mohammed Abdul-Wahhab Abdul-Razzaq Department of Internal Medicine, Faculty of Medicine, University of Kufa, Najaf, Iraq.
  • Mohammed Abed Abu Saiba Department of Internal Medicine, Faculty of Medicine, University of Kufa, Najaf, Iraq.
  • Najah R Hadi Department of Internal Medicine, Faculty of Medicine, University of Kufa, Najaf, Iraq.

DOI:

https://doi.org/10.22317/imj.v6i4.1212

Keywords:

Serum, Uric Acid, Hypertension

Abstract

Objectives: To study the association between elevated serum uric acid and systemic arterial hypertension.

Methods: This study is a case-control study conducted in Al-Sadr Teaching City / Al-Najaf city from December 2019 till the end of February 2020, and included (69) cases diagnosed with systemic arterial hypertension and (71) non- hypertensive. All participants underwent anthropometric measurements and laboratory investigations for serum uric acid level, total cholesterol, high-density lipoprotein level, triglyceride level, serum blood urea and serum creatinine.

Results: The study enrolled a total of (140) participants whose mean age was (47.21 ± 12.53) years. Males comprised (57.14%) of total study sample. Serum uric acid level was found to be significantly higher among hypertensive compared to non-hypertensive, P-value = 0.003. Hyperuricemia was found to be significantly correlated with hypertension, with P-value of 0.017, Odds ratio = 9.18 (95% C.I.: 1.12 – 75.50).

Conclusions: Serum uric acid level is significantly higher in hypertensive group compared to non-hypertensive group, with the presence of significant numbers with hyperuricemia among hypertensive patients.

 

References

Rock K, Kataoka H, Lai J. Uric acid as a danger signal in gout and its comorbidities. Nature Reviews Rheumatology. 2012;9(1):13-23.

El-Ridi R, Tallima H. Physiological functions and pathogenic potential of uric acid: A review. Journal of Advanced Research. 2017;8:487-493.

Chaudhary K, Malhotra K, Sowers J, Aroor A. Uric Acid – Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome. Cardiorenal Medicine. 2013;3:208-220.

Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. International Journal of Cardiology. 2016;213:8-14.

Puig J, Torres R, de Miguel E, Sanchez A, Bailen R, Banegas J. Uric acid excretion in healthy subjects: a nomogram to assess the mechanisms underlying purine metabolic disorders. Metabolism. 2012;61:512-518.

Hediger M, Johnson R, Miyazaki H, Endou H. Molecular Physiology of Urate Transport. Physiology. 2005;20:125-133.

Hyndman D, Liu Sh, Miner J. Urate Handling in the Human Body. Current Rheumatology Reports. 2016;18:34.

Benn C, Dua P, Gurrell R et al. Physiology of Hyperuricemia and Urate-Lowering Treatments. Frontiers in Medicine. 2018;5:160.

Becker M, Jolly M. Hyperuricemia and Associated Diseases. Rheumatic Disease Clinics of North America. 2006;32:275-293.

Desideri G, Puig J, Richette P. The management of hyperuricemia with urate deposition. Current Medical Research and Opinion. 2015;31(2):27-32.

Dong Z, Tian M, Li H et al. Association of Serum Uric Acid Concentration and Its Change with Cardiovascular Death and All-Cause Mortality. Disease Markers. 2020;2020:7646384.

Zhu Y, Pandya Bh, Choi H. Prevalence of Gout and Hyperuricemia in the US General Population. Arthritis and Rheumatism. 2011;63(10):3136-3141.

Liu H, Zhang X, Wang Y, Liu B. Prevalence of hyperuricemia among Chinese adults: a national cross-sectional survey using multistage, stratified sampling. Journal of Nephrology. 2014;27(6):653-658.

Ting K, Gill T, Keen H, Tucker G, Hill C. Prevalence and associations of gout and hyperuricaemia: results from an Australian population-based study. Internal Medicine Journal. 2016;46(5):566-573.

Dong H, Xu Y, Zhang X, Tian S. Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes. Scientific Reports. 2017;7:8822.

Richette P, Bardin Th. Gout. The Lancet. 2010;375:318-328.

Roddy E, Doherty M. Epidemiology of gout. Arthritis Research & Therapy. 2010;12:223.

de Oliveira E, Burini R. High plasma uric acid concentration: causes and consequences. Diabetology & Metabolic Syndrome. 2012;4:12.

Yu K, See L, Huang Y, Yang Ch, Sun J. Dietary Factors Associated with Hyperuricemia in Adults. Seminars in Arthritis and Rheumatism. 2008;37(4):243-250.

Beydoun M, Fanelli-Kuczmarski M, Canas J, Beydoun H, Evans M, Zonderman A. Dietary factors are associated with serum uric acid trajectory differentially by race among urban adults. British Journal of Nutrition. 2018;120(8):935-945.

Ryu K, Kang H, Kim S et al. Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea. Clinical Nutrition Research. 2014;3:56-63.

Towiwat P, Li Zh. The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout. International Journal of Rheumatic Diseases. 2015;18:495-501.

Mucci N, Giorgi G, Ceratti S, Fiz-Perez J, Mucci F, Arcangeli G. Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults. Frontiers in Psychology. 2016;7:1682.

Whelton P, Carey R, Aronow W et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2017;71(6):1269–1324.

Feig D, Kang D, Nakagawa T, Mazzali M, Johnson R. Uric Acid and Hypertension. Current Hypertension Reports. 2006;8:111-115.

Kuwabara M, Niwa K, Nishi Y et al. Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. Hypertension Research. 2014;37:785-789.

Agarwal V, Hans N, Messerli F. Effect of allopurinol on blood pressure: a systematic review and meta-analysis. Journal of Clinical Hypertension (Greenwich). 2013;15(6):435-442.

Stewart D, Langlois V, Noone D. Hyperuricemia and Hypertension: Links and Risks. Integrated Blood Pressure Control. 2019;12:43-62.

Raina S, Agarwal V, Kapoor Dh, Sharma K, Yadav R. Hypertension as Determinant of Hyperuricemia: A Case Control Study from the Sub-Himalayan Region in North India. Journal of The Association of Physicians of India. 2018;66:14-18.

El-Yassin H, Al-Sharifi Z, Al-Jebuori S. Prevalence of hyperuricemia and its correlation with cardiovascular risk factors in Iraqi subjects of karbalaa city. Journal of the Faculty of Medicine Baghdad. 2012;54(1):83-87.

Poudel B, Yadav B, Kumar A, Jha Bh, Raut K. Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: A hospital based cross sectional study. Asian Pacific Journal of Tropical Biomedicine. 2014; 4(1):59-64.

Ulmer, H., Kelleher, C. C., Fitz‐Simon, N., Diem, G., & Concin, H. (2007). Secular trends in cardiovascular risk factors: an age‐period cohort analysis of 6 98 954 health examinations in 1 81 350 Austrian men and women. Journal of internal medicine, 261(6), 566-576.

Conen, D., Wietlisbach, V., Bovet, P., Shamlaye, C., Riesen, W., Paccaud, F., & Burnier, M. . Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC public health. 2004; 4(1), 9.

Baker, Joshua F., et al. "Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?." The American journal of medicine 118.8 (2005): 816-826.

Kuwabara M. Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse. 2016;3:242-252.

Borges, R. L., Ribeiro, A. B., Zanella, M. T., & Batista, M. C. Uric acid as a factor in the metabolic syndrome. Current hypertension reports, 2010;12(2), 113-119.

Mouhamed, D. H., Ezzaher, A., Neffati, F., Douki, W., Gaha, L., & Najjar, M. F. Effect of cigarette smoking on plasma uric acid concentrations. Environmental health and preventive medicine, 2011;16(5), 307-312.

Perlstein TS, Gumieniak O, Williams GH,et al. . Uric acid and the development of hypertension: the Normative Ageing Study. Hypertension. 2006; 48: 1031-1036.

Gout and Alcohol Intake: Is There a Connection? www.Healthline.com 22/10/2018.

Sarmah, Devajit, and Booloo Sharma. "A correlative study of uric acid with lipid profile." Asian Journal of Medical Sciences 4.2 (2013): 8-14.

Peng, T. C., Wang, C. C., Kao, T. W., Chan, J. Y. H., Yang, Y. H., Chang, Y. W., & Chen, W. L. . Relationship between hyperuricemia and lipid profiles in US adults. BioMed research international, 2015.

Hou, Y. L., Yang, X. L., Wang, C. X., Zhi, L. X., Yang, M. J., & You, C. G. . Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents. Lipids in health and disease,2019; 18(1), 81.

Neki N, Tamilmani. A Study of Serum Uric Acid level in Essential Hypertension. Journal of International Medical Sciences Academy. 2015; 28(1):13.

Downloads

Published

2022-12-26

How to Cite

1.
Abdul-Wahhab Abdul-Razzaq M, Abed Abu Saiba M, R Hadi N. Assessment of serum uric acid level in patients with systemic arterial hypertension. Iraq Med J [Internet]. 2022 Dec. 26 [cited 2024 Nov. 4];6(4). Available from: https://iraqmedj.org/index.php/imj/article/view/1212

Issue

Section

Articles