Association between diabetes mellitus and knee osteoarthritis

Abstract

Objective The aim of the current work was to estimate the metabolic and hormonal parameters in osteoarthritic patients with and without diabetes mellitus.
Methods Sixty patients who visited to the National Diabetic Center/Al-Mustansirya University between 2016 and 2017 at the age of (45–65) years were employed in this study. Fasting serum glucose, glycated hemoglobin, lipid profile, alkaline phosphatase activity, serum luteinizing hormone, and follicle stimulating hormone were determined in this study.
Results A significant increase in fasting serum glucose, glycated hemoglobin, serum insulin, and homeostasis model assessment for insulin resistance was found in osteoarthritic with diabetes mellitus as compared to osteoarthritic without diabetes mellitus group, (P ≤ 0.05). While there was a significant reduction in serum luteinizing hormone and follicle stimulating hormone in osteoarthritic with diabetes mellitus as compared to osteoarthritic without diabetes mellitus group, (P ≤ 0.05). There was an elevation in serum total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, alkaline phosphatase activity, and luteinizing hormone/follicle stimulating hormone ratio in osteoarthritic with diabetes mellitus as compared to osteoarthritic without diabetes mellitus group, but it was not significant.
Conclusions This study revealed high levels of serum glucose and lipids in osteoarthritic patients with low levels of LH and FSH in osteoarthritic with diabetes mellitus, which is indicative of irregular feedback mechanism in the hypothalamic-pituitary axis of these diabetic patients.