Studying the effect of Suaeda aegyptiaca extract in comparison to the metformin on streptozotocin-nicotinamide induced type 2 diabetes rats

Abstract

Objective Type 2 diabetes mellitus is a complicated metabolic disease which affects the energy balance of the cell and consequently the
body. With 422 million affected individuals, diabetes is one of the most prevalent disorders. Various medicinal properties have been counted
for Suaeda aegyptiaca in traditional medicine. This study was conducted to comprise the effect of metformin and S. aegyptiaca extract on
some physiological factors in diabetic rats.
Methods Streptozotocin-induced diabetic rats were administrated with 100, 200 and 400 mg/kg of S. aegyptiaca extract or metformin for
the period of 4 weeks. Blood was taken from animals and levels of factors including Insulin, FBS, amylase, proteins, albumin, LDH, ALK, CPK,
Fe, Na, K, TSH and MDA were evaluated.
Results Our results indicate that with the increasing concentration of S. aegyptiaca extract, the FBS and amylase amount of sugar decrease
significantly. The mean volume of proteins in the T2 group was significantly higher than other groups and the albumin volume in T1 group
was significantly higher than other groups. The CPK volume in the T3 group is approximately same to the negative control group. The rats
treated with S. aegyptiaca extract had approximately same MDA concentration and which were higher than the metformin group.
Discussion Suaeda aegyptiaca extract can be a suitable candidate for subsequent studies to define a new therapeutic agent for treatment
of diabetes.