Effects of natural and synthetic vaginal lubricants on sperm motility and DNA Fragmentation Index: a prospective comparative study
Keywords:
coital lubricants, sperm motility, DFI, fertipro®Abstract
Objective: Infertility affects approximately 15% of couples, and in about one-third the primary cause is a male factor. Patients undergoing infertility investigations frequently experience sexual dysfunction, which often is due to inadequate vaginal lubrication. This can lead to increased use of coital lubricants. Sperm motility is one of the best prognostic indicators of fertilization and DNA Fragmentation Index (DFI) is index that showed cellar and intracellular health. in this study we evaluated effects of such lubricants on sperm motility and DNA Fragmentation Index (DFI).
Methods: Twenty Semen samples from normozoospermic donors were catched. Each sample is divided to 5 group. Each tube first incubated in modified human tubal fluid (mHTF) and after treated by 10% KY jelly, Mineral oil (Fertipro®), sesame and olive oils and normal saline as negative control Groups. Total sperm motility and DNA Fragmentation Index (DFI) was evaluated 30 minutes of incubation.
Results: Control negative samples exhibited no significant decrease in sperm motility. All of group showed significant motility decreases (P<0.001). But amount of decrease was different in groups that mean differ with 95% confidence interval of sidak post hoc Analysis showed it clear. Fertipro ® and Natural oil was not significant increase the DFI. and slight drop in Motility after 30 minutes. Total sperm motility significantly declined under KY jelly and olive oil, but not significant drop in sesame oil incubation. All other lubricants had significantly higher DFI than Fertipro and controlled group of sperms.
Conclusion: Sesame and olive oil and KY jelly coital lubricants impaired sperm motility but only KY jelly® may hamper fertility. Fertipro® showed no deleterious effect and may be considered sperm-friendly coital lubricants with least DFI increment compared with controlled group. Natural oil such as olive and sesame oil like Fertipro® have a little effect on DFI although effect on motility is considerable. We should consider that natural oil was use as cured product and more study such as pharmaceutical formulation adjusted of these product is needed. So Fertipro® can be used to relieve vaginal dryness and preserve fertility.
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