Controlling the levels of oxidative DNA damage improves patient’s response to simvastatin therapy in primary male infertility
Keywords:
Male infertility, oxidative DNA damage, 8-hydroxydeoxyguanosine, simvastatin therapyAbstract
Objectives Male primary infertility can occur for several reasons. In most of the cases, sperm sample examination itself may give information
about the underlying cause, but it would not help in determining the management plan. Simvastatin treatment can help to reduce the
degree of oxidative stress and improve sperm outcome. 8-hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative DNA damage that
can be used to assess the level of oxidative stress and the patient’s response to a course of treatment.
Methods This is a randomized controlled trial study, which included 90 participants (55 males with primary infertility and a matching of 35
control subjects). The patients were recruited from Al-Najaf Teaching Hospital, Iraq. Patients were provided with simvastatin tablets (20 mg
× once daily for 12 weeks). Semen samples were taken to assess sperm parameters such as morphology, motility and motility. In addition,
urinary samples were also collected to measure levels of 8-OHdG, before and after the simvastatin treatment course.
Results This study showed significant reduction in the levels of urinary 8-OHdG in the patient group compared to the control group after
the treatment course.
Conclusion This study provides evidence about the beneficial use of simvastatin to improve the sperms’ outcome in males with primary
infertility. In addition, the useful measurement of urinary 8-OHdG is to monitor the degree of oxidative stress and patient’s response to
medication.
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