Diagnosis of Breast Cancer by some remarkable enzymes


  • Parween Abdulsamad Ismail Department of Chemistry, College of Education, University of Salahadine, Erbil, Iraq.
  • Araz Muhammad Yousif Department of Basic Science, Dentistry College, Hawler Medical University, Erbil, Iraq.




Breast cancer, remarkable enzymes


Objectives: This study aimed to evaluate the activity of several remarkable enzymes in the serum of breast cancer and estimate their  potential value in the diagnosis of breast cancer.
Methods: The study comprised of 70 patients with  breast cancer and 50 age and sex-matched healthy subjects as controls. Levels of (5 –Nucleotidase), Acid phosphatase activity (ACP), Glutamate dehydrogenase (GDH), Serum β-glucuronidase, Aldehyde dehydrogenase (ALDH), Alcohol Dehydrogenase (ADH), Superoxide dismutase (SOD) and Adenosine deaminase ADA were measured  using enzymatic methods.
Results: There was a significant increase in the Catalytic activities of 5 –Nucleotidase((p<0.001), ACP ( p< 0.05), GDH ( ≤0.001 p), Serum β-glucuronidase (p<0.0001), ADH ( p< 0.001), SOD (p< 0.001))and ADA(p< 0.001),while there was no significant increase in the level of Aldehyde dehydrogenase (ALDH)( p = 0.231)in sera of breast cancer patients compared to the control.
Conclusion: The present study strongly indicates the potential role of SOD, GDH, ADH, GDH,5–Nucleotidase,GLU and ACP as important biomarkers in breast cancer.


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How to Cite

Ismail, P. A., & Yousif, A. M. (2021). Diagnosis of Breast Cancer by some remarkable enzymes. Iraq Medical Journal, 5(3), 101–103. https://doi.org/10.22317/imj.v5i3.1056




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