Diagnosis of Breast Cancer by some remarkable enzymes

Authors

  • Parween Abdulsamad Ismail Department of Chemistry, College of Education, University of Salahadine, Erbil, Iraq.
  • Araz Muhammad Yousif Department of Basic Science, Dentistry College, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.22317/imj.v5i3.1056

Keywords:

Breast cancer, remarkable enzymes

Abstract

Objectives: This study aimed to evaluate the activity of several remarkable enzymes in the serum of breast cancer and estimate their  potential value in the diagnosis of breast cancer.
Methods: The study comprised of 70 patients with  breast cancer and 50 age and sex-matched healthy subjects as controls. Levels of (5 –Nucleotidase), Acid phosphatase activity (ACP), Glutamate dehydrogenase (GDH), Serum β-glucuronidase, Aldehyde dehydrogenase (ALDH), Alcohol Dehydrogenase (ADH), Superoxide dismutase (SOD) and Adenosine deaminase ADA were measured  using enzymatic methods.
Results: There was a significant increase in the Catalytic activities of 5 –Nucleotidase((p<0.001), ACP ( p< 0.05), GDH ( ≤0.001 p), Serum β-glucuronidase (p<0.0001), ADH ( p< 0.001), SOD (p< 0.001))and ADA(p< 0.001),while there was no significant increase in the level of Aldehyde dehydrogenase (ALDH)( p = 0.231)in sera of breast cancer patients compared to the control.
Conclusion: The present study strongly indicates the potential role of SOD, GDH, ADH, GDH,5–Nucleotidase,GLU and ACP as important biomarkers in breast cancer.

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Published

2021-09-26

How to Cite

1.
Ismail PA, Yousif AM. Diagnosis of Breast Cancer by some remarkable enzymes. Iraq Med J [Internet]. 2021 Sep. 26 [cited 2024 Nov. 21];5(3):101-3. Available from: https://iraqmedj.org/index.php/imj/article/view/1056

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