Association between Calprotectin and Cystatin C levels with kidney injury Molecule-1 and their effects on developments of COVID-19 complications

Authors

  • Hawraa Fadhil Abbas Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Kerbala, Iraq.
  • Fadhil Jawad Al-Tu'ma Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Kerbala, Iraq.
  • Riyadh Mohei Al-Saiegh Section of Nephrology, Department of Internal Medicine, College of Medicine, University of Kerbala, Kerbala, Iraq.
  • Maha Mohammed Kadhim Al-Tu’ma Department of Anesthesia Techniques, College of Health and Medical Techniques, Al-Zahraa University for Women, Kerbala, Iraq.

DOI:

https://doi.org/10.22317/imj.v6i3.1199

Keywords:

Leukocyte L1 Antigen Complex, Cystatin C, COVID-19, Pathogenesis

Abstract

Objectives: This work aimed to study the association between KIM-1, Calprotectin and Cystatin C and other biomarkers and their roles for early detection of the severity of Covid-19 associated with kidney injury complications that lead to death in severe Covid- 19 patients.

Methods: This study included 91 samples patients with Covid-19 divided into two group, 46 patients of them with severe Covid-19 and 45 patients of them with moderate infected Covid-19 include (56 male, 35 female) with a matched age ranged between (22-88) years patients. The study was conducted from Al-hayat unit, Al-Hussein Teaching Hospital, Al-Hussein Medical City during the period from (Oct., 2020 to July., 2021). The biomarkers determined include: ferritin, C-reactive protein (CRP), total lactate dehydrogenase (LDH) activity, creatinine, urea, cystatin C (Cys C), calprotectin (CLP), and kidney injury molecule-1 (KIM-1) beside complete blood count test (CBC) which were determined by using various biochemical techniques including ELISA.                                                Results: The results of data which include 46 patients with severe Covid-19 group and another 45 patients with moderate Covid-19 infection, there is significant data obtained for ferritin, LDH and RDW-CV when compare between severe and moderate group of Covid-19 patients (p<0.05) while other parameter showed a non-significant increased result. There is positive correlation between KIM-1 and Cys C in severe and moderate group (p< 0.01) and with creatinine (p<0.01) and urea (p<0.05) in severe Covid-19 group, and significant correlation between Cys C and creatinine in severe group (p<0.05).

Conclusion: There is a significant correlation between KIM-1 and CysC and serum creatinine with Cys. C and KIM-1. Also, the obtained results illustrated that CLP, Cys C and KIM-1were non-significant increase in Covid-19 patients groups, but ferritin and LDH had increment significantly when compare between severe and moderate group and can be served as parameter predictor and increased mortality risk for Covid-19 patients.                                                                                                                                 

References

Chen, Yu; Liu, Qianyun; Guo, Deyin. Emerging coronaviruses: genome structure, replication, and pathogenesis. Journal of medical virology, 2020, 92.4: 418-423.‏

Gralinski, Lisa E.; Menachery, Vineet D. Return of the Coronavirus: 2019-nCoV. Viruses, 2020, 12.2: 135.‏

Ciaccio, Marcello; Agnello, Luisa. Biochemical biomarkers alterations in Coronavirus disease 2019 (Covid-19). Diagnosis, 2020, 7.4: 365-372.‏

Joaninidis, Michael, et al. Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup. Intensive care medicine, 2020, 46.4: 654-672.‏

Ometto, Francesca, et al. Calprotectin in rheumatic diseases. Experimental Biology and Medicine, 2017, 242.8: 859-873.‏

Chen, Liting, et al. Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in Covid-19 patients. Cellular and molecular immunology, 2020, 17.9: 992-994

Barrett, A. J. The cystatins: a diverse superfamily of cysteine peptidase inhibitors. Biomedica biochimica acta, 1986, 45.11-12: 1363-1374.‏

Liu, J. Evaluation of serum cystatin C for diagnosis of acute rejection after renal transplantation. In: Transplantation proceedings. Elsevier, 2012. p. 1250-1253.‏

Ingelfinger, Julie R.; Marsden, Philip A. Estimated GFR and risk of death—is Cystatin C useful?. The New England journal of medicine, 2013, 369.10: 974.‏

Brooks, Craig R., et al. KIM‐1‐/TIM‐1‐mediated phagocytosis links ATG 5‐/ULK 1‐dependent clearance of apoptotic cells to antigen presentation. The EMBO journal, 2015, 34.19: 2441-2464.‏

Ichimura, Takaharu, et al. Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. The Journal of clinical investigation, 2008, 118.5: 1657-1668.‏

Carfora, Vincenzo, et al. Anticoagulant treatment in Covid-19: a narrative review. Journal of thrombosis and thrombolysis, 2021, 51.3: 642-648.‏

Noman W. A., Ali H. A., Mahdi A. B. Zabibah R. S., and Ali R. A. The Association between Serum Levels of Ferritin and D-Dimer with Liver Function Tests in Patients with Covid-19, 2021, Clin Schizophr Relat Psychoses, 15(4):2-6.

Mohsin H. S., Ali H. A., and Al-Tu'ma F. J. (2021) Assessment of von Willebrand Factor/ADAMTS13 Ratio and Vitamin K Levels as Predictor Markers for Severity of Covid-19 Patients, 2021 JOCMS, (In press).

Wu, Zunyou; Mcgoogan, Jennifer M. Characteristics of and important lessons from the coronavirus disease 2019 (Covid-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA, 2020, 323.13: 1239-1242

Wu, Chaomin, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA internal medicine, 2020, 180.7: 934-943.‏

Zhao, Yu, et al. Single-cell RNA expression profiling of ACE-2, the putative receptor of Wuhan 2019-nCov. BioRxiv, 2020.‏

Gagliardi, Maria Cristina, et al. ACE-2 expression and sex disparity in Covid-19. Cell Death Discovery, 2020, 6.1: 1-2.‏

Seys, Leen JM, et al. DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients. Clinical Infectious Diseases, 2018, 66.1: 45-53.‏

Lippi, Giuseppe; Henry, Brandon Michael. Active smoking is not associated with severity of coronavirus disease 2019 (Covid-19). European journal of internal medicine, 2020, 75: 107-108.‏

Schmid, Marcello FS; Gernand, Jill; Kakaral, Radhika. The use of the pulse oximetric saturation to fraction of inspired oxygen ratio in an automated acute respiratory distress syndrome screening tool. Journal of critical care, 2015, 30.3: 486-490.‏

Fisher, Molly, et al. AKI in hospitalized patients with and without Covid-19: a comparison study. Journal of the American Society of Nephrology, 2020, 31.9: 2145-2157.‏

Yang, Xianghong, et al. Prevalence and impact of acute renal impairment on Covid-19: a systematic review and meta-analysis. Critical Care, 2020, 24.1: 1-8.‏

Fontanill, John; Han, Won K. Kidney injury molecule-1 as an early detection tool for acute kidney injury and other kidney diseases. Expert Opinion on Medical Diagnostics, 2011, 5.2: 161-173.‏

Iyare, Rachel Nkem; Volskiy, Vladimir; Vandenbosch, Guy AE. Study of the correlation between outdoor and indoor electromagnetic exposure near cellular base stations in Leuven, Belgium. Environmental research, 2019, 168: 428-438.‏

Anjaneyulu, Muragundla; Chopra, Kanwaljit. Quercetin, an anti‐oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clinical and Experimental pharmacology and physiology, 2004, 31.4: 244-248.‏

Kopec-Medrek, Magdalena; Widuchowska, Małgorzata; Kucharz, Eugeniusz J. Calprotectin in rheumatic diseases: a review. Reumatologia, 2016, 54.6: 306.‏

Nikolakopoulou, Zacharoula, et al. Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery. Biomarkers in medicine, 2019, 13.3: 205-218.‏

Sabbisetti, Venkata S., et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. Journal of the American Society of Nephrology, 2014, 25.10: 2177-2186.‏

Qin, Lu, et al. Gendered effects on inflammation reaction and outcome of Covid‐19 patients in Wuhan. Journal of medical virology, 2020, 92.11: 2684-2692.‏

Liu, Yingxia, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences, 2020, 63.3: 364-374.‏

Tan, Chaochao, et al. C‐reactive protein correlates with computed tomographic findings and predicts severe Covid‐19 early. Journal of medical virology, 2020, 92.7: 856-862.‏

Zhang, Haibo, et al. Angiotensin-converting enzyme 2 (ACE-2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive care medicine, 2020, 46.4: 586-590.‏

Wirtz, Theresa H., et al. Association of serum calprotectin concentrations with mortality in critically ill and septic patients. Diagnostics, 2020, 10.11: 990.‏

Chen, Liting, et al. Elevated serum levels of S100A8/A9 and HMGB1 at hospital admission are correlated with inferior clinical outcomes in Covid-19 patients. Cellular and molecular immunology, 2020, 17.9: 992-994.‏

Fisher, Molly, et al. AKI in hospitalized patients with and without Covid-19: a comparison study. Journal of the American Society of Nephrology, 2020, 31.9: 2145-2157.‏

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Published

2022-09-26

How to Cite

1.
Abbas HF, Al-Tu'ma FJ, Al-Saiegh RM, Al-Tu’ma MMK. Association between Calprotectin and Cystatin C levels with kidney injury Molecule-1 and their effects on developments of COVID-19 complications. Iraq Med J [Internet]. 2022 Sep. 26 [cited 2024 Nov. 4];6(3). Available from: https://iraqmedj.org/index.php/imj/article/view/1199

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