Association between Protein Kinase C –B Isoform Level and Insulin Resistance in Pathogenesis of Iraqi Patients with Type 2 Diabetic Nephropathy Complications

Authors

  • Zahraa Abdul Adheem Al-Maiyaly Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Kerbala, Iraq.
  • Fadhil Jawad Al-Tu’ma Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Kerbala, Iraq.
  • Amir F. Al-Tu’ma Department of Medical and Health Laboratories, College of Medical and Health Technologies, Ahlulbait University, Kerbala, Iraq.

DOI:

https://doi.org/10.22317/imj.v5i1.980

Keywords:

Diabetic Nephropathy, Type 2 Diabetes Mellitus, PKC-B, Insulin Resistance

Abstract

Objective:  The aim of the present study is to evaluate the association between serum PKC-B isoform activity levels and various biomarkers such as insulin resistance in sera of Iraqi patients with diabetic nephropathy complications.

Methods: A cross-sectional study was performed on 100 samples obtained from Al-Hussein Teaching Hospital, Al-Hussein Medical City, Kerbala Health Directorates / Kerbala – Iraq during Nov., 2019 to Sep. 2020. Thirty patients have type 2 diabetic nephropathy, 40 patients with type 2 diabetic without nephropathy and 30 samples as apparently healthy control. Biochemical data, comprising serum PKC-B level, lipid profile, blood glucose, insulin, HOMA-IR  and renal function tests such as urea, creatinine and GFR were investigated.

Results: The study included 63% male and 37% female. The results indicated that there was a significant difference in blood glucose, HbA1c%, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), urea, creatinine, GFR and PKC-B between diabetic nephropathy and non-diabetic nephropathy groups (P-value <0.05). Serum PKC-B activity was significantly correlated with blood glucose, HOMA-IR, creatinine and GFR among diabetic nephropathy group, while, HbA1c% and blood glucose was positively correlated with PKC-B level in non-diabetic nephropathy  group.

Conclusion: The observed data conclude that PKC-B level is higher in patients with diabetic nephropathy complication as compared with T2DM and healthy control. Also there is a significant correlation between PKC-B level and renal function tests in DN group which indicate an important role of PKC-B level in pathogenesis of diabetic nephropathy complications.

Downloads

Published

2021-03-26

How to Cite

1.
Al-Maiyaly ZAA, Al-Tu’ma FJ, Al-Tu’ma AF. Association between Protein Kinase C –B Isoform Level and Insulin Resistance in Pathogenesis of Iraqi Patients with Type 2 Diabetic Nephropathy Complications. Iraq Med J [Internet]. 2021 Mar. 26 [cited 2024 Nov. 4];5(1). Available from: https://iraqmedj.org/index.php/imj/article/view/980

Issue

Section

Articles

Similar Articles

1 2 3 4 5 > >> 

You may also start an advanced similarity search for this article.