Locally Aggressive Case of Ameloblastoma with 15 Years Follow-Up: A Case Report


  • Fahmi M. Salih Oncology department, Rizgary Teaching Hospital, Erbil, Kurdistan Region, Iraq
  • Hawro Taha Hamza Oncology department, Nanakali Hospital for Blood Diseases & Cancer, Erbil, Kurdistan Region, Iraq
  • Sami Saleem Omar Oncology department, Rizgary Teaching Hospital, Erbil, Kurdistan Region, Iraq
  • Hana Rizgar Mohammed Ameen Oncology department, Rizgary Teaching Hospital, Erbil, Kurdistan Region, Iraq
  • Rivan H. Isaac Histopathology department, Rizgary Teaching Hospital Erbil, Kurdistan Region, Iraq
  • Khursheed Khrwatany Maxillofacial Surgery depatment, Rizgary Teaching Hospital, Erbil, KRG, Iraq
  • Kakil Ibrahim Rasul Senior Consultant Haem/Oncologist at National Center for Cancer Care and Research, Doha, Qatar




Ameloblastoma, Recurrence, Case report, Radiotherapy


Ameloblastomas (AM) are the most common benign odontogenic tumors with local invasion and high recurrence rates, which generally
occur in the jawbones. Although most cases occur between ages 20 and 40, AM can still occur in children at a much lower incidence.
Ameloblastomas typically exhibit an aggressive nature, with the potential to infiltrate the jawbone and present as a noticeable tumor.1
About 1% of oral tumors are found to be ameloblastoma.2 This paper presents a case report of a 40-year-old female diagnosed with a giant ameloblastoma of the left lower mandible who had multiple surgeries done for local recurrences over 15 years duration.


Palanisamy JC, Jenzer AC. Ameloblastoma - StatPearls - NCBI Bookshelf [Internet]. 2023 Available from: https://www.ncbi.nlm.nih.gov/books/NBK545165/

Masthan KMK, Anitha N, Krupaa J, Manikkam S. Ameloblastoma [Internet]. U.S. National Library of Medicine; 2015 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439660/#ref11

Soluk-Tekkesin, M.; Wright, J.M. The World Health Organization classification of odontogenic lesions: A summary of the changes of the 2022 (5th) edition. Turk. J. Pathol. 2022, 38, 168–184. [Google Scholar]

Chawla R, Ramalingam K, Sarkar A, Muddiah S. Ninety-one cases of Ameloblastoma in an Indian population: A comprehensive review [Internet]. U.S. National Library of Medicine; 2013 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783771/

Thuckanaickenpalayam Ragunathan Y, Keniyan Kumar S, Janardhanam D, Ravi A, Santhanam V, Ramdas MN. Prevalence and epidemiological profile of Ameloblastoma in India: A systematic review and meta-analyses [Internet]. U.S. National Library of Medicine; 2022 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930951/

Faras F, Abo-Alhassan F, Israël Y, Hersant B, Meningaud JP. Multi-recurrent invasive ameloblastoma: A surgical challenge. Int J Surg Case Rep. 2017;30:43–45. doi:10.1016/j.ijscr.2016.11.039

Gravvanis, A.; Koumoullis, H.D.; Anterriotis, D.; Tsoutsos, D.; Katsikeris, N. Recurrent giant mandibular ameloblastoma in young adults. Head Neck 2016, 38, E1947–E1954. [Google Scholar] [CrossRef ]

Ghai S. Ameloblastoma: An Updated Narrative Review of an Enigmatic Tumor. Cureus. 2022;14(8):e27734. Published 2022 Aug 6. doi:10.7759/cureus.27734.

Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO. Ameloblastoma: current etiopathological concepts and management. Oral Dis. 2018;24(3):307–316. doi:10.1111/odi.12646 10. Kurppa, Kari J., et al. “High frequency of BRAF V600E mutations in ameloblastoma.” The Journal of pathology 232.5 (2014): 492–498.

Vered M, Muller S, Heikinheimo K. IARC WHO Classification of Tumours. 4th Edition, Volume 9. Vol. 215. Lyon, France: IARC Press; 2017. Ameloblastoma;p. 8.

Pandiar D, Anand R, Kamboj M, Narwal A, Shameena PM, Devi A. Metastasizing ameloblastoma: a 10-year clinicopathological review with an insight into pathogenesis. Head Neck Pathol. 2021;15:967–974.

Wright JM, Soluk Tekkesin M. Odontogenic tumors: where are we in 2017? J Istanb Univ Fac Dent. 2017;51:0–30.

McClary AC, West RB, McClary AC, et al. Ameloblastoma: a clinical review and trends in management. Eur Arch Otorhinolaryngol. 2016;273:1649–1661.

Yang R, Liu Z, Gokavarapu S, Peng C, Ji T, Cao W. Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma. Chin J Cancer Res. 2017;29:189–195.

Li D, Xu S, Sun M, Qiao L, Wang L, Liu Y. MAID chemotherapy regimen as a treatment strategy for metastatic malignant ameloblastoma: A case report. Medicine (Baltimore). 2019 Jun;98(25):e15873. doi: 10.1097/MD.0000000000015873. PMID: 31232921; PMCID: PMC6636961.

Amzerin M, Fadoukhair Z, Belbaraka R, Iraqui M, Boutayeb S, M’rabti H, Kebdani T, Hassouni K, Benjaafar N, El Gueddari BK, Errihani H. Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature. J Med Case Rep. 2011 Oct 3;5:491. doi:10.1186/1752-1947-5-491. PMID: 21968082; PMCID: PMC3198715.

Heikinheimo K, Kurppa KJ, Elenius K. Novel targets for the treatment of ameloblastoma. J Dent Res. 2015 Feb;94(2):237–40. doi:10.1177/0022034514560373. Epub 2014 Nov 25. PMID: 25425580; PMCID: PMC4438731.

Almeida Rde A, Andrade ES, Barbalho JC, Vajgel A, Vasconcelos BC. Recurrence rate following treatment for primary multicystic ameloblastoma: systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2016;45:359–367.

Troiano G, Dioguardi M, Cocco A, et al. Conservative vs radical approach for the treatment of solid/multicystic ameloblastoma: a systematic review and meta-analysis of the last decade. Oral Health Prev Dent. 2017;15:421–426.

Singh MA, Shah A, Bhattacharya A, Raman R. (PDF) Treatment algorithm for Ameloblastoma - ResearchGate [Internet]. 2014 Available from: https://www.researchgate.net/publication/270291071_Treatment_Algorithm_for_Ameloblastoma




How to Cite

M. Salih, F. ., Taha Hamza, H. ., Saleem Omar, S. ., Rizgar Mohammed Ameen, H. ., H. Isaac, R. ., Khrwatany, K. ., & Ibrahim Rasul, K. . (2024). Locally Aggressive Case of Ameloblastoma with 15 Years Follow-Up: A Case Report . Iraq Medical Journal, 7(4). https://doi.org/10.22317/imj.v7i4.1260