Sclerosing Central Mucoepidermoid Carcinoma: Rare Case Series and Review

Central Mucoepidermoid Carcinoma


  • Azhar Haleem Environmental Research Center, University of Technology, Baghdad, Iraq.
  • Rana R Al-Ani Environmental Research Center, University of Technology, Baghdad, Iraq.



mucoepidermoid carcinoma, case reports, salivary glands, PAS stains



The most frequent malignant tumour of the salivary glands is mucoepidermoid carcinoma which accounts for 30% of all malignancies of the salivary glands. There are numerous histologic variations with various levels of differentiation. Sclerosing MEC (SMEC) is a rare subtype of MEC that has the potential to be misdiagnosed as a low-grade non-SMEC malignancy or a benign reactive condition. There have been no cases of the extremely rare sclerosing variant of central or intraosseous MEC reported as of yet.

Case reports:

We present two cases of Sclerosing Central MEC, in which histologic analysis revealed relatively well-circumscribed, nonencapsulated tumours made up of dispersed epithelial islands of low-grade MEC and extensive central sclerosis. Similar sclerotic stroma was present in the tumor in the second case, but the epithelial component was of intermediate grade. Both cases showed abundant intracytoplasmic mucin and positive Mayer mucicarmine and PAS stains.


Sclerosing central mucoepidermoid carcinoma was identified as the cause. Both cases underwent a complete resection of the tumor and have since been free of the disease.


Simon D, Somanathan T, Ramdas K, Pandey M. Central Mucoepidermoid carcinoma of mandible–A case report and review of the literature. World journal of surgical oncology. 2003 Dec; 1(1):1-5.

Veras EF, Sturgis E, Luna MA. Sclerosing mucoepidermoid carcinoma of the salivary glands. Annals of diagnostic pathology. 2007 Dec 1;11(6):407-12.

Ide F, Horie N, Shimoyama T, Saito I. Sclerosing mucoepidermoid carcinoma: specific histologic variant or nonspecific morphologic pattern? Oral Medicine & Pathology. 2011;15(2):53-5.

Zhou CX, Chen XM, Li TJ. Central mucoepidermoid carcinoma: a clinicopathologic and immunohistochemical study of 39 Chinese patients. The American journal of surgical pathology. 2012 Jan 1;36(1):18-26.

Mardi K, Madan S. Sclerosing mucoepidermoid carcinoma of the submandibular gland: report of two rare cases. Clinical Cancer Investigation Journal. 2012 Apr 1;1(2):86.

Bhat K, Pandey B, Shetty P, Manohar V, Shruthilaxmi MK, Patidar M. Sclerosing mucoepidermoid carcinoma: a unique case. Sultan Qaboos University Medical Journal. 2014 May;14(2): e249.

Sepulveda I, Frelinghuysen M, Platin E, Spencer ML, Compan A, Munzenmayer J, Ulloa D. Mandibular central mucoepidermoid carcinoma: A case report and review of the literature. Case reports in oncology. 2014;7(3):732-8.



How to Cite

Haleem, A., & Al-Ani, R. R. . (2023). Sclerosing Central Mucoepidermoid Carcinoma: Rare Case Series and Review: Central Mucoepidermoid Carcinoma. Iraq Medical Journal, 7(1), 24–27.



Case Report