Frontiers in early detection of hepatocellular carcinoma
DOI:
https://doi.org/10.22317/imj.v6i4.1206Keywords:
Carcinoma, Hepatocellular, alpha-Fetoproteins, Apoptosis, lysosomal enzymes, Extracellular MatrixAbstract
Description of the article
The need for more precise serodiagnosis marker for hepatocellular carcinoma (HCC) is always a must for many reasons:
- Serodiagnosis is generally non-invasive and safe technique to have a human sample.
- Different radiological modalities, although its accuracy is progressing, but many times its result is misinterpreted.
- The current extensively used seromarker, alpha fetoprotein (AFP), doesn’t exceed 70% for sensitivity and 90% for specificity.
- Many of clinicians requesting AFP tests, whether in HCC management or related diseases, as, hepatitis C or B infections don’t know exactly the diagnostic accuracy levels of AFP.
- The need for spectrophotometric marker, rather than molecular or radio or Elisa parameter as a cost effective goal.
- The earlier the detection of HCC, the longer the patient life.
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