Frontiers in early detection of hepatocellular carcinoma

Authors

  • Nabil Mohie Abdel-Hamid Biochemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Egypt.
  • Luma Abd Almunim Baker Chemistry Department, Faculty of Education, University of Mosul, Mosul, Iraq.
  • Lelas Farhan Bdaiwi Chemistry Department, Faculty of Education for Girls , University of Mosul, Mosul, Iraq.

DOI:

https://doi.org/10.22317/imj.v6i4.1206

Keywords:

Carcinoma, Hepatocellular, alpha-Fetoproteins, Apoptosis, lysosomal enzymes, Extracellular Matrix

Abstract

Description of the article  

The need for more precise serodiagnosis marker for hepatocellular carcinoma (HCC) is always a must for many reasons:

  • Serodiagnosis is generally non-invasive and safe technique to have a human sample.
  • Different radiological modalities, although its accuracy is progressing, but many times its result is misinterpreted.
  • The current extensively used seromarker, alpha fetoprotein (AFP), doesn’t exceed 70% for sensitivity and 90% for specificity.
  • Many of clinicians requesting AFP tests, whether in HCC management or related diseases, as, hepatitis C or B infections don’t know exactly the diagnostic accuracy levels of AFP.
  • The need for spectrophotometric marker, rather than molecular or radio or Elisa parameter as a cost effective goal.
  • The earlier the detection of HCC, the longer the patient life.

References

Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet 2012;379:1245-55.

Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatology international 2017;11:317-70.

Abdel-Hamid NM, Abouzied MM, Nazmy MH, Fawzy MA, Gerges AS. A suggested guiding panel of seromarkers for efficient discrimination between primary and secondary human hepatocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016;37:2539-46.

Abdel Hamid NM, Nazmy, M.H , Moustafa, B.E. and Saad El-din, S.M. Priority of Alpha-L- Fucosidase Over Alpha fetoprotein in Early Detection of Hepatocellular Carcinoma in Animals and Human. Acta Oncol Tur 2014;47 1-7.

Abdel-Hamid NM, Abdel-Fattah, SM, Nazmy, MH and Mahmoud, AS. Extracellular glycosaminoglycans in management of primary hepatocellular carcinoma rather than alpha fetoprotein. . J Dis Markers 2016;3:1036-40.

Abdel-Hamid NM, Shehata DE, Abdel-Ghany AA, Ragaa A, Wahid A. Serum serotonin as unexpected potential marker for staging of experimental hepatocellular carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016;83:407-11.

Abdel-Hamid N, O. M. Mohafez, OM, S. Zakaria, S and Thabet, K. Hepatic somatostatin receptor 2 expression during premalignant stages of hepatocellular carcinoma. . Tumor Biol 2014 35:2497-502.

Abdel-Hamid NM, El-Moselhy MA, El-Baz A. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International journal of hepatology 2011;2011:736581.

Downloads

Published

2022-12-26

How to Cite

1.
Mohie Abdel-Hamid N, Abd Almunim Baker L, Farhan Bdaiwi L. Frontiers in early detection of hepatocellular carcinoma. Iraq Med J [Internet]. 2022 Dec. 26 [cited 2024 Nov. 4];6(4). Available from: https://iraqmedj.org/index.php/imj/article/view/1206

Issue

Vol. 6 No. 4 (2022): Autumn 2022

Section

Short Communications

License

Copyright (c) 2022 Iraq Medical Journal

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.