The Effectiveness of Nitric Oxide Loaded by Silica Nanoparticles with β-Sitosterol and Aloe Vera Gel for Treatment Burn Wound

Authors

  • Laith A. Younus Department of Clinical Laboratory Sciences, Faculty of Pharmacy, Jabir Ibn Hayyan for Medical and Pharmaceutical Sciences, Al Najaf Al Ashraf, Iraq.

DOI:

https://doi.org/10.22317/imj.v8i3.1289

Keywords:

Nitric Oxide, β-Sitosterol, Burn, Silica Nanoparticles, and Aloe Vera Gel.

Abstract

Objective:
To investigate the efficacy of nitric oxide nanoparticles (NO-np) and β-sitosterol, delivered via aloe vera hydrogel, as a topical treatment for burn wounds, leveraging nitric oxide's antibacterial, anti-inflammatory, and wound-healing properties.

Methods:
Using a rat burn model, the study evaluated the antibacterial effect of NO against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus in vitro. Burn healing was assessed by applying a combination of NO-np, β-sitosterol, and aloe vera gel to the wounds, comparing treated samples to control groups. Histological analysis was performed to assess tissue regeneration and angiogenesis in the treated areas.

Results:
The NO-np exhibited significant antibacterial activity by inhibiting the growth of the tested bacteria. Additionally, the combination of NO-np, β-sitosterol, and aloe vera gel accelerated wound healing in burn injuries, with significant improvement in healing speed (P<0.05) and enhanced angiogenesis compared to controls.

Conclusion:
This study suggests that nitric oxide-loaded silica nanoparticles, especially when combined with β-sitosterol and delivered via aloe vera hydrogel, hold promise as an effective topical treatment for cutaneous burns. This combination therapy enhances wound healing, reduces burned tissue, and promotes angiogenesis, indicating potential for clinical application in burn management.

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Published

2025-01-03

How to Cite

1.
Younus LA. The Effectiveness of Nitric Oxide Loaded by Silica Nanoparticles with β-Sitosterol and Aloe Vera Gel for Treatment Burn Wound. Iraq Med J [Internet]. 2025 Jan. 3 [cited 2025 Jan. 5];8(3). Available from: https://iraqmedj.org/index.php/imj/article/view/1289

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