Assessment of spermatozoal oxidative stress response to simvastatin in male infertility
Keywords:
Male infertility, lipid peroxidation, simvastatin therapyAbstract
Objectives: In ability to conceive may be caused by either female or male problems. The aim of this study is to evaluate the effects of simvastatin medication on improving the degree of lipid peroxidation in patients with primary infertility and improving sperm formation and maturation.
Methods: This is a randomized controlled study. It included 90 participants, fifty-five male patients whom diagnosed with primary infertility matched with thirty-five normal control subjects. The patients were randomly selected from Al-Najaf Teaching Hospital, Iraq. The patients were divided into eight groups based on the cause of infertility. Patients were supplied by 20mg simvastatin tablets once daily for a period of 12 weeks. Semen samples were assessed for lipid peroxidation before and after the course of the treatment.
Results: There was a negative correlation between spermatozoal malondialdehyde level and percentage of active sperm motility. This was associated with a positive correlation between spermatozoal malondialdehyde level and abnormal sperm morphology.
Conclusion: The current study suggests that simvastatin medication may be usefully administer to reduce the levels of lipid peroxidation in infertile males to improve sperm formation and maturation.
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