Concordance of core needle biopsy and post-operative histo-pathological grading in breast cancer patient

Abstract

Objectives: This study aimed to evaluate the concordance of histological types, grade and components of grading, between CNB and open surgical specimens.

Methods: In this study patients with paired CNB and open surgical biopsy diagnosed with invasive breast cancer are involved, from January 2012 to October 2015 were recreated. Revision of (579) patients were done, but only (116) patients were included in our study according to inclusion criteria, in the breast center department of Slemani Teaching Hospital in Slemani Governorate.

Results: There were 116 patients with invasive breast cancer analyzed for concordance rate  between CNB and open surgical specimen for tumor type, grade, tubule formation, nuclear pleomorphism, and mitotic count were 93.1%, 73.3%, 77.6%, 73.3%, 62.9% respectively, mitotic count was under estimated in CNB samples(kappa 0.4  P value 0.001).

Conclusion: These results indicate that pre-operative CNB can reliably provide useful preoperative prognostic and predictive information in breast cancer patients which can play a major role in planning treatment strategies. Core needle biopsy has significant accuracy in determining invasive breast cancer and histological type and grading.