Antidiabetic, Hepato-Protective and Hypolipidemic Effects of Eryngium Caucasicum Extract in Streptozotocin-Nicotinamide Induced Type 2 Diabetes in Male Rats

Abstract

Objective: The purpose of this study was to evaluate anti-diabetic, hepato-protective and hypolipidemic effects of Eryngium Caucasicum extract in nicotinamide-streptozotocin induced type 2 diabetes mellitus model in Wistar rats.

Methods: In this study, sixty adult male Wistar rats (150 – 250 g) were randomly allocated into six groups (n=10) including: 1: Healthy Control rats, 2: Diabetic control, 3: diabetic rats which received Sitagliptine, 4, 5 and 6: diabetic rats which received respectively 100, 200 and 300 mg/kg oral gavage of E. Caucasicum extract for 30 days. Diabetes was induced by intraperitoneal injection of nicotinamide and streptozotocin. At the end of experiment, blood samples were collected and fasting blood sugar, insulin, hepatic enzymes, lipid profile and insulin-like growth factor were measured.

Results: Administration of Eryngium Caucasicum in type 2 diabetes mellitus animal models can affect insulin secretion, insulin related indices and lipid profile. Liver enzymes not only did not increase but also decreased significantly. Additionally, E. Caucasicum increased insulin-like growth factor serum level in a dose dependent manner. On the whole, it seems that E. Caucasicum affects diabetes in rats in a dose-dependent manner, as higher doses showed better effects.

Conclusions: Here we showed that administration of E. Caucasicum in type 2 diabetes mellitus animal model has antidiabetic, hypolipidemic and hepato-protective effects which maybe in a dose-dependent manner.