Evaluation of the role of serum uric acid in patients with multiple sclerosis; An Observational case-control study

Authors

  • Nawfal Madhi Sheaheed Division of Neurology, Baghdad teaching hospital, Medical City, Baghdad, Iraq.
  • Ammar M. Halomi Division of Neurology, Baghdad teaching hospital, Medical City, Baghdad, Iraq.
  • Akram M. Almahdawi Division of Neurology, Baghdad teaching hospital, Medical City, Baghdad, Iraq.

DOI:

https://doi.org/10.22317/imj.v3i4.721

Keywords:

Multiple sclerosis, Uric acid, Nitric oxide, Peroxynitrite

Abstract

Objectives: To evaluate the role of uric acid in patients with MS as an investigational marker in true relapse events.

Methods: 108 patients with relapsing-remitting and Secondary progressive MS, compared to case-control of about 120 patients (manifested other neurological diseases OND) who were included in this study which was conducted from March 2008 to July 2009 at Baghdad Teaching Hospital multiple sclerosis clinic. A study protocol sheet was done and filled from the patient's database in the MS clinic.

Results: In the overall MS group, serum UA levels were lower than in controls, the difference did reach statistical significance (P=0.01). Serum UA was found to be lower in patients during relapse than when they are in remission. The mean serum UA level from patients after one month of follow up shows an inverse correlation with MS type, age, and EDSS score, and positive correlation with gender and clinical activity, but none of these correlations reach statistical significance.

Conclusions: The question whether reduced serum UA level in MS is a primary deficit or an epiphenomenon remains open. Despite the fact that UA level was lower in clinically-documented active patients, a general mean UA decrease is evident also in clinically and MRI inactive MS patients as compared to OND.

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Published

2019-12-26

How to Cite

Sheaheed, N. M., Halomi, A. M., & Almahdawi, A. M. (2019). Evaluation of the role of serum uric acid in patients with multiple sclerosis; An Observational case-control study. Iraq Medical Journal, 3(4). https://doi.org/10.22317/imj.v3i4.721

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