Para-vertebral intramuscular platelet rich plasma vs. subcutaneous ozone injection for chronic low back pain

Authors

  • Abdullah Ahmed Mohammad Al-Mansoor primary health center, Kirkuk, Iraq
  • Hayder Ghali Wadi Algawwam Emergency.it ONG Onlus, Sulaymaniyah, Iraq

Keywords:

Back pain, Pain Management, Platelets Rich Plasma, Ozone, Iraq

Abstract

Objectives This study aimed to investigate the comparison between Para-vertebral intramuscular platelet rich plasma and subcutaneous ozone injection for patients with chronic low back pain.

Methods This is a retrospective study of 102 patients (68 females and 34 males) with severe chronic LBP treated by subcutaneous ozone or para-vertebral IM-PRP in a private clinic in Kirkuk, Iraq over 2 years period (July 1st, 2016–June 30th, 2018). A sample of patient’s own blood was used to prepare PRP by a process of two repeated centrifugation. Longevity resources EXT50 Ozone Generator with oxygen tank and CGA870 Oxygen Regulator were used. The response to therapy was graded as excellent, good, fair and poor.

Results The mean age was 52.5± 1.5 years. Two thirds of patients received PRP and one third received O3. Three injections were sufficient to get fair, good and excellent response in all patients managed with para-vertebral I.M PRP injection, while most of the patients (79.4%) treated with subcutaneous ozone injection required six injections to get such responses. Although 88.2% of patients had at least one co-morbid condition, no patient experienced a poor response in either group. Conclusion Although Ozone and PRP are inexpensive therapies, they seem to be safe and effective in palliating chronic LBP pain.

References

1. Aufiero D, Vincent H, Sampson S, Bodor M. Regenerative Injection Treatment in the Spine: Review and Case Series with Platelet Rich Plasma. J Stem Cells Res, Rev & Rep 2015;2(1):1019
2. Russo M, Deckers K, Kiesel K, Gilligan C, Vieceli J, et al. Muscle Control and Non‐specific Chronic Low Back Pain. Neuromodulation: Technology at the Neural Interface 2017; 21(1):1-9
3. Crawford RJ, Volken T, Valentin S, Melloh M, Elliott JM. Rate of lumbar paravertebral muscle fat infiltration versus spinal degeneration in asymptomatic populations: an age aggregated cross-sectional simulation study. Scoliosis and Spinal Disorders 2016;11.1-9.
4. Hauser RA, Hauser MA. Dextrose Prolotherapy for Unresolved Low Back Pain: A Retrospective Case Series Study. Journal of Prolotherapy 2009;1(3):145-155
5. Velio Bocci (2005). Ozone a new medical drug. 1st. Edition. Springer, p: 200
6. Mohammad AA. Clinical applications of ozone: a review of 94 cases from Iraq. Iraq MedJ. 2018;2(1):10–14
7. Zambello A, Fara B, Bianchi M, Tabaracci G. Paravertebral Oxygen-Ozone Infiltrations: High versus Low Doses: towards the Minimum Effective Dose A Retrospective Study 2007; 6 (1): 37-41.
8. Cameron JA, Thielen KM. Autologous Platelet Rich Plasma for Neck and Lower Back Pain Secondary to Spinal Disc Herniation: Midterm Results. Midterm Results. Spine Res. 2017; 2: 1-5.
9. Madrid declaration on ozone therapy in five languages (2015). 2nd. Edition ISCO3.
10. Zelman DC, Dukes E, Brandenburg N, Bostrom A, Gore M. Identification of cut-points for mild, moderate and severe pain due to diabetic peripheral neuropathy. Pain 2005;115:29–36.
11. Bocci V, Borrelli E, Zanardi I, Travagli V. The usefulness of ozone treatment in spinal pain. Drug Design, Development and Therapy 2015; 9: 2677–2685.
12. Weglein AD. Neural Prolotherapy. Journal of Prolotherapy 2011; 3 (2): 936.
13. Mohammed S, Yu J. Platelet-rich plasma injections: an emerging therapy for chronic discogenic low back pain. Journal of Spine Surgery 2018; 4(1):115-122.
14. Chou L, Brady SR, Urquhart DM, Teichtahl AJ, Cicuttini FM, Pasco JA et al. The Association Between Obesity and Low Back Pain and Disability Is Affected by Mood Disorders. Medicine (Baltimore) 2016 Apr; e3367 2016; 95 (150: 1-7.
15. Auburn A, Benjamin S, Bechtel R. A New Approach for Injecting Patients with Low Back Pain using Prolotherapy Agents: Functional Prolotherapy. Journal of Prolotherapy 2009;1(3):181-183
16. Imamura M, Imamura ST, Targino RA, Morales-Quezada L, Tomikawa LC, Tomikawa LG et al. Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial. J Pain 2016; 17(5): 569–576
17. Noci JB. Spinal Ozone Therapy in Lumbar Spinal Stenosis. International Journal of Ozone Therapy 2007; 6: 17-24.
18. Hussein M, Hussein T. Effect of autologous platelet leukocyte rich plasma injections on atrophied lumbar multifidus muscle in low back pain patients with monosegmental degenerative disc disease. SICOT J 2016; 2: 12
19. Hauser RA, Lackner JB, Steilen-Matias D, Harris DK. A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 2016; 9: 139–159.

Downloads

Published

2019-09-14

How to Cite

1.
Mohammad AA, Algawwam HGW. Para-vertebral intramuscular platelet rich plasma vs. subcutaneous ozone injection for chronic low back pain. Iraq Med J [Internet]. 2019 Sep. 14 [cited 2024 Nov. 21];3(2). Available from: https://iraqmedj.org/index.php/imj/article/view/640

Issue

Section

Articles

Similar Articles

<< < 11 12 13 14 15 16 17 > >> 

You may also start an advanced similarity search for this article.