Proinf lammatory cytokines and oxidative stress are key participant in recurrent spontaneous abortion

Abstract

Objective To evaluate the association of oxidative stress/impaired antioxidant defense system and inflammation with the occurrence of recurrent spontaneous abortion (RSA).
Methods This study consisting of 30 pregnant women with a history of RSA (study group) and 30 healthy pregnant women (control group), their age ranging from 15 to 45 years. Blood samples were collected and tested for the measurement of antioxidants (SOD, CAT), MPO and proinflammatory cytokines. Student t-test was used for statistical analysis.
Results Serum levels of SOD and CAT were significantly lower (P < 0.05) and serum level of MPO was significantly higher (P < 0.05) in the study group as compared with the control group. A significant increase in TNF levels was observed (P > 0.05) between the two studied and control group, while IL-6 levels change was non-significant.
Conclusions Our data demonstrate that reduction impaired antioxidant defense and elevation of MPO and TNF, and the presence of possible interrelationship between those parameters may be related at least partly to the pathogenesis of RSA.