Toxopathological effects of camphor on some organs of female rats

Abstract

Objective: The histological change of the effects camphor on some organs of female rats.
In Iraq camphor in the form of tablets was added to wash dead bodies, and thus putting washers in great risk, especially female washers. Though, literature concerning its histological toxicity has not been documented. It has long been used in dead bodies washed, in our study we used camphor to kndewledge to effect high dose from camphor on histological change in some organs.
Methods: The rats were divided into 3 groups (n = 6), the first group (A) was a control group treated with D.W., the second and third groups (B and C), treated with 50 mg camphor/kg and 75 mg camphor/kg. At the end of one month of treatment, animals were anesthetized, liver ,kidney, spleen and ovary were removed for serial sections and histological staining.
Results: Showed vaculation in hepatocytes, and infiltration of inflammatory cells loss of most of the architecture and loss of cell boundaries in liver of group (B), while in group (C) there was congestion in area of Portia, detachment of some hepatocytes and inflammatory cells. Kidney of group B showed edematous glomerulus, glomerular lobulation, and increase number of nuclei. Also, there was swollen glomerulus, increase number of uclei and congestion of blood cells in kidney of group C. Spleen of groups B and C revealed non active lymphoid tissue and degenerated lymphocytes cells, congestion in lymphoid tissue and depletion of white pulp mainly neutrophils and macrophage. Also the results showed congestion in follicles (B) and hemorrhage (C), detachment in oocytes in treatment groups compared with control group.
Conclusions: The oral administration of varying concentration of camphor solution to the animal rat has a cytotoxic effect on organs such as ,the liver, kidney, spleen and ovary.